منابع مشابه
Sense and sensitisation: in vitro testing for hepatotoxic drug hypersensitivity.
Sense and sensitisation: in vitro testing for hepatotoxic drug hypersensitivity Over 30 years ago, small lymphocytes were observed to transform into larger, more granular cells and undergo proliferation in the presence of antigen in vitro. 1 This rapidly formed the basis of a laboratory test to detect sensitised lymphocytes. 2 In this system, mononuclear cells are separated from a patient's per...
متن کاملAssessment of hepatotoxic potential.
Philosophic concepts and pragmatic approaches toward improved understanding of the effect of drugs in the hepatocyte are reviewed. No set pattern of studies is advocated but rather observations are encouraged within the framework of studies that provide for varied exposure of the hepatocyte. Clinical usage should be imitated to provide earliest possible indications of toxicity in man. The need ...
متن کاملVitamin E and hepatotoxic agents
I . It has been suggested that carbon tetrachloride damages rat liver by accelerating processes of lipid peroxidation at subcellular sites and that the protective action of vitamin E is due to its functioning as an antioxidant in vivo. Direct evidence for these mechanisms in vivo has been sought and is critically examined. 2. The increased production of malondialdehyde by rat liver microsomal f...
متن کاملIs black cohosh a hepatotoxic medicinal herb?
Recently, the European Medicines Agency (EMEA) and the Committee on Herbal Medicinal Products (HMPC) have released a public statement to draw the attention of European health authorities to 42 cases (34 directly reported from European national competent authorities and 8 published) of suspected hepatotoxic reactions to Cimicifugae racemosae rhizoma (black cohosh, root) in patients, probably all...
متن کاملAssessment of hepatotoxic liabilities by transcript profiling.
Male Wistar rats were treated with various model compounds or the appropriate vehicle controls in order to create a reference database for toxicogenomics assessment of novel compounds. Hepatotoxic compounds in the database were either known hepatotoxicants or showed hepatotoxicity during preclinical testing. Histopathology and clinical chemistry data were used to anchor the transcript profiles ...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1968
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(68)80078-2